Chromosome movement: Kinetochores motor along
نویسندگان
چکیده
منابع مشابه
Chromosome movement: Kinetochores motor along
The equal division of chromosomes among daughter cells at mitosis involves a complex series of kinetochore-dependent chromosome movements. The kinetochore-associated CENP-E motor protein is critical for the sustained movement of chromosomes towards the metaphase plate during chromosome congression.
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The Ndc80 complex is a key component of the kinetochore-microtubule interface. Two studies now demonstrate that a conserved loop region within the extended coiled-coil of Ndc80 plays an unexpected role in recruiting proteins to the kinetochore.
متن کاملKinetochores accelerate centrosome separation to ensure faithful chromosome segregation.
At the onset of mitosis, cells need to break down their nuclear envelope, form a bipolar spindle and attach the chromosomes to microtubules via kinetochores. Previous studies have shown that spindle bipolarization can occur either before or after nuclear envelope breakdown. In the latter case, early kinetochore-microtubule attachments generate pushing forces that accelerate centrosome separatio...
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During mitosis in cultured newt pneumocytes, one or more chromosomes may become positioned well removed (greater than 50 microns) from the polar regions during early prometaphase. As a result, these chromosomes are delayed for up to 5 h in forming an attachment to the spindle. The spatial separation of these chromosomes from the polar microtubule-nucleating centers provides a unique opportunity...
متن کاملCENP-E Function at Kinetochores Is Essential for Chromosome Alignment
CENP-E is a kinesin-like protein that binds to kinetochores and may provide functions that are critical for normal chromosome motility during mitosis. To directly test the in vivo function of CENP-E, we microinjected affinity-purified antibodies to block the assembly of CENP-E onto kinetochores and then examined the behavior of these chromosomes. Chromosomes lacking CENP-E at their kinetochores...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1998
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(98)70243-x